D-500 Homogenizer Head Selection Guide

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D-500 High Shear Homogenizer Head Selection Guide

The BIOSTELLAR D-500 High Shear Homogenizer is designed for laboratory homogenization, solid-liquid dispersion, and emulsification. It is widely used in pharmaceutical, biotechnology, cosmetics, food, and chemical research for sample preparation and formulation development.

With interchangeable dispersion heads, the D-500 offers flexible configurations for different sample types and processing volumes. This guide introduces three common combinations to help you choose the right setup for your application.

1. Three Common Dispersion Head Configurations

Application	Recommended Combination	Working Volume	Main Purpose
Solid-liquid mixing	S20C / SR20	10–5000 mL	Dispersing solids into liquids and preparing suspensions
Emulsification	S20F / ER20	10–5000 mL	Mixing immiscible liquids to prepare emulsions
Small-sample solid-liquid mixing	SS5C / SR5	1–50 mL	Processing small quantities of laboratory samples

2. Application and Selection Guide

Solid-Liquid Mixing: S20C / SR20

Suitable for dispersing powders, particles, and other solid materials into liquid media.

Typical applications: Pharmaceutical formulation research; pigment and material dispersion; food ingredient mixing; cosmetic ingredient preparation.

Choose this configuration when your primary objective is to prepare suspensions or improve the distribution of solid particles in liquids.

Emulsification: S20F / ER20

Designed for laboratory emulsification involving immiscible liquids, such as oil and water. The rotor-stator system generates mechanical shear to help disperse one liquid phase into another.

Typical applications: Cream and lotion development; food emulsion preparation; pharmaceutical formulation research; chemical product development.

Choose this configuration when your main processing objective is liquid-liquid emulsification.

Small-Sample Processing: SS5C / SR5

Designed for small-volume solid-liquid mixing and sample homogenization, with a working volume of 1–50 mL.

Typical applications: Biotechnology research; small-volume sample preparation; preliminary formulation testing; laboratory method development.

Choose this configuration when sample quantities are limited or when working with small laboratory vessels.

3. How to Choose the Right Head

Sample type: Determine whether your application involves solid-liquid mixing, emulsification, or small-sample processing.
Working volume: Confirm your minimum and maximum sample volumes.
Material properties: Consider viscosity, particle characteristics, and phase composition.
Processing objectives: Define the required dispersion or emulsification results.
Vessel compatibility: Check vessel dimensions and recommended operating conditions.

For specialized applications, other configurations may also be considered according to your sample characteristics and experimental requirements. Confirm compatibility with the supplier before ordering.

Conclusion

The appropriate D-500 dispersion head depends on your sample type and processing objectives:

S20C / SR20: Solid-liquid mixing, 10–5000 mL.
S20F / ER20: Emulsification, 10–5000 mL.
SS5C / SR5: Small-sample solid-liquid mixing, 1–50 mL.

BIOSTELLAR supports laboratory equipment selection for different sample preparation requirements.

Contact our team with your sample type and working volume to discuss a suitable configuration.

The BIOSTELLAR D500 Laboratory High Shear Homogenizer is designed for laboratory-scale dispersion, emulsification and sample homogenization. Its rotor–stator system operates at 10,000–30,000 rpm with six selectable speed levels, allowing users to adapt the mixing intensity to different sample requirements. A 550 W motor, detachable dispersing components and automatic overload protection make it a practical choice for formulation research, quality control and routine sample preparation.